Serum copper, ceruloplasmin and monoamine oxidase in diabetics with different times of evolution of the disease.

Ia 103 diabetics simultaneous measurements of serum copper and ceruloplasmin were made, together with the determination of glucose, cholesterol and monoamine oxidase. These diabetics were divided ia two groups: 53 had a diagnosis made iess than two years ago, and 50 had diabetes diagnosed for more than 10 years. A contrcil group consisted in 50 normal individuaIs. Copper and ceruloplasmin of diabetic sera are more elevated than in normal individuais. This elevation is statistically significant. There is a positive correiation between copper and ceruloplasmin, both in normal individuals and in diabetics. Serum copper is more elevated in diabetics with iess than two years of evolution than in diabetics with more than 10 years of evolution. The opposite happens with serum monoamine oxidase. Serum cholesterol is not significantiy eievated in diabeti~s.